Monday, September 19, 2011

Online gamers help scientists unravel AIDS-related enzyme

I'm going to copy and paste an entire article here.  The source for the article is Yahoo! News .  Normally I don't do this, but I've seen too many of these "news" articles expire and disappear, and I don't want it to happen to this one.

This article illustrates two things.  The first thing is a "serious game," a ten-percent slice of the gaming industry, where gaming hardware and software is used to do serious work.  And this is a pretty exciting serious game.  The second thing is an intersection between gamers and scientists, showing how the power of online gaming can be harnessed to benefit society.  No, seriously.  Okay, there's a third thing.  This is a phenomenon known as crowdsourcing, where someone turns a crowd of marginally-skilled people loose on a problem that is way beyond their individual capabilities, and working as an unorganized crowd, they are able to solve the problem.

Okay, on with the show.

Online gamers have achieved a feat beyond the realm of Second Life or Dungeons and Dragons: they have deciphered the structure of an enzyme of an AIDS-like virus that had thwarted scientists for a decade.
The exploit is published on Sunday in the journal Nature Structural & Molecular Biology, where -- exceptionally in scientific publishing -- both gamers and researchers are honoured as co-authors.
Their target was a monomeric protease enzyme, a cutting agent in the complex molecular tailoring of retroviruses, a family that includes HIV.
Figuring out the structure of proteins is vital for understanding the causes of many diseases and developing drugs to block them.
But a microscope gives only a flat image of what to the outsider looks like a plate of one-dimensional scrunched-up spaghetti. Pharmacologists, though, need a 3-D picture that "unfolds" the molecule and rotates it in order to reveal potential targets for drugs.
This is where Foldit comes in.
Developed in 2008 by the University of Washington, it is a fun-for-purpose video game in which gamers, divided into competing groups, compete to unfold chains of amino acids -- the building blocks of proteins -- using a set of online tools.
To the astonishment of the scientists, the gamers produced an accurate model of the enzyme in just three weeks.
Cracking the enzyme "provides new insights for the design of antiretroviral drugs," says the study, referring to the lifeline medication against the human immunodeficiency virus (HIV).
It is believed to be the first time that gamers have resolved a long-standing scientific problem.
"We wanted to see if human intuition could succeed where automated methods had failed," Firas Khatib of the university's biochemistry lab said in a press release.
"The ingenuity of game players is a formidable force that, if properly directed, can be used to solve a wide range of scientific problems."
One of Foldit's creators, Seth Cooper, explained why gamers had succeeded where computers had failed.
"People have spatial reasoning skills, something computers are not yet good at," he said.
"Games provide a framework for bringing together the strengths of computers and humans. The results in this week's paper show that gaming, science and computation can be combined to make advances that were not possible before."

Again, I did not write this.  Yahoo! News owns the copyright.  If they ask me to delete it, I will comply and rewrite the story in my own words.  But they did a fine job at it, and I'd prefer not to change a single word.

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